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A promoter. If the NH2-terminus is sufficient to confer Cullin binding specificity, all chimeras with the same NH2-terminal Roc sequence should bind the same Cullins, regardless of the RING domain to which they are fused. We transfected these constructs into S2 cells and determined Cullin binding by IP/immunoblot. Because we had already observed that Roc1a binds Cul1 and Cul3 but not Cul5, thatRoc
1
A promoter. If the NH2-terminus is sufficient to confer Cullin binding specificity, all chimeras with the same NH2-terminal Roc sequence should bind the same Cullins, regardless of the RING domain to which they are fused. We transfected these constructs into S2 cells and determined Cullin binding by IP/immunoblot. Because we had already observed that Roc1a binds Cul1 and Cul3 but not Cul5, thatRoc
1
Do you want a shiny, new car in your driveway? Are you worried about how hard it is to buy one? We wrote this article with you in mind, and the advice here will make buying your next car a process which you not only enjoy, but leaves you with an amazing car at a great price.



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Ebellum, and ventral midbrain of rats following treatment with intraperitoneal injected or orally drinking with aluminum chloride [26]. The results of the present study indicated that administration of high concentration AlCl3 induced higher levels of Al accumulation in the brain stem. Consistent with previous studies on adult rats, distribution of Al mainly occurred in 3 specific areas in neonata
1
F the IDP domain containing an asparagine and proline (Asn- and Pro)-rich region, with glycine (Gly)- and glutamine (Gln)-rich repeats mid-sequence is implicated in self- assembly. Based on analytical ultracentrifugation, the glycine-rich region oligomerizes to form large protein assemblies. The proline-rich region also shows a self-Author Manuscript Author Manuscript Author Manuscript Author Manu
1
F the IDP domain containing an asparagine and proline (Asn- and Pro)-rich region, with glycine (Gly)- and glutamine (Gln)-rich repeats mid-sequence is implicated in self- assembly. Based on analytical ultracentrifugation, the glycine-rich region oligomerizes to form large protein assemblies. The proline-rich region also shows a self-Author Manuscript Author Manuscript Author Manuscript Author Manu
1
Ebellum, and ventral midbrain of rats following treatment with intraperitoneal injected or orally drinking with aluminum chloride [26]. The results of the present study indicated that administration of high concentration AlCl3 induced higher levels of Al accumulation in the brain stem. Consistent with previous studies on adult rats, distribution of Al mainly occurred in 3 specific areas in neonata
1
F the IDP domain containing an asparagine and proline (Asn- and Pro)-rich region, with glycine (Gly)- and glutamine (Gln)-rich repeats mid-sequence is implicated in self- assembly. Based on analytical ultracentrifugation, the glycine-rich region oligomerizes to form large protein assemblies. The proline-rich region also shows a self-Author Manuscript Author Manuscript Author Manuscript Author Manu
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